Identification of a Selective PDE4B Inhibitor From Bryophyllum pinnatum by Target Fishing Study and In Vitro Evaluation of Quercetin 3-O-α-L-Arabinopyranosyl-(1→2)-O-α-L-Rhamnopyranoside
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منابع مشابه
Hepatoprotective Effects of Kaempferol-3-O-α-l-Arabinopyranosyl-7-O-α-l-Rhamnopyranoside on d-Galactosamine and Lipopolysaccharide Caused Hepatic Failure in Mice.
Fulminant hepatic failure (FHF), associated with high mortality, is characterized by extensive death of hepatocytes and hepatic dysfunction. There is no effective treatment for FHF. Several studies have indicated that flavonoids can protect the liver from different factor-induced injury. Previously, we found that the extracts of Elaeagnus mollis leaves had favorable protective effects on acute ...
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Benzyl α-l-rhamnopyranoside 4, obtained by both conventional and microwave assisted glycosidation techniques, was subjected to 2,3-O-isopropylidene protection to yield compound 5 which on benzoylation and subsequent deprotection of isopropylidene group gave the desired 4-O-benzoylrhamnopyranoside 7 in reasonable yield. Di-O-acetyl derivative of benzoate 7 was prepared to get newer rhamnopyranos...
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The title compound, C(13)H(24)O(10) is the methyl glycoside of a structural element α-l-Fucp-(1→ 3)-α-d-Galp making up two thirds of the repeating unit in the capsular polysaccharide of Klebsiella K63. The conformation of the title compound is described by the glycosidic torsion angles ϕ(H) = 55 (1)° and ψ(H) = -24 (1)°. The hy-droxy-methyl group in the galactose residue is present in the gauch...
متن کاملMethyl 3-O-α-l-fucopyranosyl β-d-glucopyranoside tetrahydrate
The title compound, C(13)H(24)O(10)·4H(2)O, is the methyl glycoside of a disaccharide structural element present in the backbone of the capsular polysaccharide from Klebsiella K1, which contains only three sugars and a substituent in the polysaccharide repeating unit. The conformation of the title disaccharide is described by the glycosidic torsion angles ϕ(H) = 51.1 (1)° and ψ(H) = 25.8 (1)°. ...
متن کاملMethyl 4-O-benzyl-α-l-rhamnopyranoside
In the title compound, C14H20O5, an inter-mediate in the synthesis of oligosaccharides, the glycosidic [H-C-O-C(H3)] torsion angle ϕH is 52.3° and the exo-cyclic [H-C-O-C(H2)] torsion angle θH is -11.7°. The hexa-pyran-ose ring has a chair conformation. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, forming chains propagating along [010]. Enclosed within the chains are R 3 (3)(1...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2020
ISSN: 1663-9812
DOI: 10.3389/fphar.2019.01582